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KMID : 0043320120350091553
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Archives of Pharmacal Research
2012 Volume.35 No. 9 p.1553 ~ p.1558
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Ingenane-type diterpenes with a modulatory effect on IFN-γ production from the roots of Euphorbia kansui
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Khiev Piseth
Kim Jae-Wha
Sung Song-Jae
Song Hyuk-Hwan
Choung Dong-Ho
Chin Young-Won
Lee Hyeong-Kyu
Oh Sei-Ryang
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Abstract
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A new ingenane-type diterpene, (3S,5R)5-O-(2,3-dimethylbutanoyl)-13-O-dodecanoyl-20-O-deoxyingenol (1), and six known compounds,3-O-(2,3-dimethylbutanoyl)-13-O-dodecanoyl-20-O-deoxyingenol (2), 20-O-decanoylingenol (3), 20-O-acetylingenol-3-O-(2′E,4′Z) decadienoate (4), kansuiphorin A (5), 3-O-(2,3-dimethylbutanoyl)-13-O-dodecanoylingenol (6), and kansuinin F (7) were isolated and evaluated for their effect on IFN-γ production in NK92 cells. Interestingly, subjection to compounds 4 and 6 (10 nM) displayed the most significant response in IFN-γ production, comparable to that produced by the same dose of phorbol 12-myistate 13-acetate (PMA). High doses of compounds 3 (100 nM), 1 (1. 25 μM) and 5 (5.0 μM) have also been shown to activate the IFN-γ production.
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KEYWORD
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Euphorbia kansui, Euphorbiaceae, Ingenane-type diterpenes, IFN-γ
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